Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/23280
Title: S-Score: A Scoring System for the Identification and Prioritization of Predicted Cancer Genes
Authors: Souza, Jorge E. S. de
Fonseca, André F.
Valieris, Renan
Carraro, Dirce M.
Wang, Jean Y. J.
Kolodner, Richard D.
Souza, Sandro J. de
Keywords: cancer genes;S-Score;The Cancer Genome Atlas;oncogenes
Issue Date: 7-Apr-2014
Portuguese Abstract: A new method, which allows for the identification and prioritization of predicted cancer genes for future analysis, is presented. This method generates a gene-specific score called the "S-Score" by incorporating data from different types of analysis including mutation screening, methylation status, copy-number variation and expression profiling. The method was applied to the data from The Cancer Genome Atlas and allowed the identification of known and potentially new oncogenes and tumor suppressors associated with different clinical features including shortest term of survival in ovarian cancer patients and hormonal subtypes in breast cancer patients. Furthermore, for the first time a genome-wide search for genes that behave as oncogenes and tumor suppressors in different tumor types was performed. We envisage that the S-score can be used as a standard method for the identification and prioritization of cancer genes for follow-up studies.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/23280
Appears in Collections:ICe - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
SScore_A Scoring System for the Identification and Prioritization of Predicted Cancer Genes.pdfSandroSouza_ICe_SScore A Scoring System_2014720.15 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.