CCS - DNUT - Artigos publicados em periódicos
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Artigo Breast milk retinol levels after Vitamin A supplementation at different postpartum amounts and intervals(Nutrients, 2022) Ribeiro, Karla Danielly da S.; Bezerra, Danielle S.; Melo, Andressa T. A. de; Oliveira, Kátia C. de A. N. de; Araújo, Karoline Q. M. A. de; Medeiros, Monalisa S. M. de F.; Santos, Flávia A. P. S. dos; Medeiros, Jeane F. P.; Lima, Mayara S. R.; Silva, Ana Gabriella C. L. da; Dimenstein, Roberto; Osório, Mônica M.; 0000-0002-2251-5967Maternal vitamin A (VA) supplementation in risk areas for Vitamin A deficiency (VAD) was launched to improve the level of this nutrient in nursing mothers and in their breast milk. This longitudinal and randomized study aimed to evaluate the levels of retinol in breast milk after supplementation with VA in varying amounts (200,000 IU or 400,000 IU) and different postpartum intervals. Women were distributed into four intervention groups and given a single 200,000 IU postnatal dosage of VA at time 0 h (postnatal morning) (G200 0H); a single 200,000 IU dosage of VA in week four (G200 4W); 200,000 IU of VA at time 0 h + 200,000 IU of VA 24 h after the first supplementation (G400 24H); and 200,000 IU of VA at time 0 h + 200,000 IU of VA one week after the first supplementation (G400 1W). Breast milk samples were collected over a 12-week period (0 h, 24 h and 1, 4, 12 weeks post-natal). Retinol levels were determined by high-performance liquid chromatography. The Generalized Estimated Equation (GEE) assessed the different retinol levels. The G200 (0H), G400 (24H), and G400 (1W) groups presented higher retinol levels at 24 h than the G200 (4W) group (p < 0.001). The retinol levels of all groups were similar at times 1, 4 and 12 weeks after delivery (p > 0.05). Maternal VA supplementation increased retinol levels in the colostrum. Different supplementation dosages or postpartum administration times did not result in added benefit to retinol levels in mature breast milk.Artigo Crescimento intrauterino e status de vitamina E de recém-nascidos a termo e pré-termo(Revista de Pediatria Paulista, 2019) Ribeiro, Karla Danielly da Silva; Medeiros, Jeane Franco Pires; Lima, Mayara Santa Rosa; Mata, Amanda Michelly Braga da; Silva, Alyne Batista da; Andrade, Eva Débora de Oliveira; Bezerra, Danielle Soares; Osório, Mônica Maria; Dimenstein, Roberto; 0000-0002-2251-5967Objetivo: Determinar a concentração de alfatocoferol em soro de cordão umbilical de recém-nascidos a termo e pré-termo, a fim de avaliar o estado nutricional de ambos os grupos com relação a essa vitamina e sua possível correlação sobre o crescimento intrauterino. Métodos: Estudo observacional de caráter transversal realizado com 140 recém-nascidos, 64 pré-termo e 76 a termo, sem malformações, oriundos de mães saudáveis, não fumantes e com parto de concepto único. O crescimento intrauterino foi avaliado pelo índice peso por idade gestacional ao nascer, utilizando a Intergrowth-21st. Os níveis de alfatocoferol do soro do cordão umbilical foram analisados por cromatografia líquida de alta eficiência. Resultados: A concentração média de alfatocoferol no soro do cordão umbilical para recém-nascidos pré-termo e a termo foi de, respectivamente, 263,3±129,5 e 247,0±147,6 μg/dL (p=0,494). Baixos níveis de vitamina E foram encontrados em 95,3% dos prematuros e em 92,1% dos neonatos a termo. No grupo pré‐termo, 23% eram pequenos para a idade gestacional, enquanto no grupo a termo esse percentual foi de apenas 7% (p=0,017). Não houve correlação entre os níveis de alfatocoferol e o escore Z de peso para idade gestacional (p=0,951). Conclusões: Não foi encontrada associação entre os níveis de alfatocoferol e a adequação do peso à idade gestacional ao nascer. A restrição do crescimento intrauterino foi mais frequente nos nascidos pré-termo, e a maioria dos recém-nascidos apresentou níveis baixos de vitamina E no momento do parto.Artigo Determination of tocopherols and physicochemical properties of faveleira (Cnidoscolus quercifolius) seed oil extracted using different methods(Food Science and Technology, 2019) Ribeiro, Karla Danielly da Silva; Silva, Denise Maria de Lima e; Dantas, Mariana Mesquita; Ribeiro, Penha Patrícia Cabral; Dimenstein, Roberto; Damasceno, Karla Suzanne Florentino da Silva Chaves; 0000-0002-2251-5967This study aims to evaluate the physicochemical properties and tocopherol content in faveleira seed oil extracted using three methods (Bligh-Dyer, Soxhlet extractor, and cold-pressing). Each of the methods generated different yield percentages, with cold-pressing producing the least amount of oil. However, the cold-pressing method produced better quality oil with more desirable properties, including low acidity (1.56 ± 0.01% oleic acid) and low peroxide value (0.45 ± 0.09 mEq/1000 g). Cold-pressing resulted in higher quantities of tocopherols: 0.59 ± 0.12 mg/100 g of alpha-tocopherol and 20.97 ± 1.15 mg/100 g of beta + gamma-tocopherol. Faveleira seed oil, when extracted by cold-pressing, maintains better physicochemical quality, with the highest beta + gamma-tocopherol content.Artigo Factors associated with increased alpha-tocopherol content in milk in response to maternal supplementation with 800 IU of vitamin E(Nutrients, 2019) Ribeiro, Karla Danielly da Silva; Rebouças, Amanda de Sousa; Silva, Ana Gabriella Costa Lemos da; Oliveira, Amanda Freitas de; Silva, Lorena Thalia Pereira da; Felgueiras, Vanessa de Freitas; Cruz, Marina Sampaio; Silbiger, Vivian Nogueira; Dimenstein, Roberto; 0000-0002-2251-5967Background: Vitamin E supplementation might represent an efficient strategy to increase the vitamin E content in milk. The present study aimed to evaluate the impact of supplementation with 800 IU RRR-alpha-tocopherol on the alpha-tocopherol content of milk and the factors associated with the increase in vitamin E. Methods: Randomized clinical trial with 79 lactating women from Brazil, who were assigned to the control group, or to the supplemented group (800 IU of RRR-alpha-tocopherol). Milk and serum were collected between 30 and 90 days after delivery (collection 1), and on the next day (collection 2). Alpha-tocopherol was analyzed using high-performance liquid chromatography. Results: In the supplemented group, the alpha-tocopherol content in serum and milk increased after supplementation (p < 0.001). In the multivariate analysis, only alpha-tocopherol in milk (collection 1) was associated with the level of this vitamin in milk after supplementation (β = 0.927, p < 0.001), and binary logistic regression showed that the dietary intake was the only determinant for the greater effect of supplementation in milk. Conclusion: The pre-existing vitamin level in milk and diet are determinants for the efficacy of supplementation in milk, suggesting that in populations with vitamin E deficiency, high-dose supplementation can be used to restore its level in milk.Artigo Impacto da COVID-19 na segurança alimentar e nutricional: desafios e estratégias emergentes(Research, Society and Development, 2021) Ribeiro, Karla Danielly da Silva; Silva, Ana Gabriella Costa Lemos da; Oliveira, Tatiana Maria de; Cáceres, Aylen Evelin Mendoza; Lima, Severina Carla Vieira Cunha; Lyra, Clélia de Oliveira; 0000-0002-2251-5967Objetivo: discutir sobre o impacto da pandemia da COVID-19 na segurança alimentar e nutricional (SAN) das populações, mostrando os desafios enfrentados e quais as estratégias emergentes dos países para impedir a expansão da insegurança alimentar durante e após essa crise social e sanitária. Metodologia: revisão narrativa realizada através de uma busca bibliográfica de artigos em português e inglês, disponíveis nas bases de dados PubMed, Scielo, Embase e Lilacs. Foram incluídos artigos publicados sem data limite de publicação e os quais se encontravam disponíveis na íntegra. Os descritores utilizados foram: “Segurança alimentar e nutricional”, “Insegurança alimentar”, “Pandemia” e “COVID-19”. Resultados: medidas para controlar os surtos da COVID-19 afetaram as cadeias de abastecimento de alimentos. Além disso, altos níveis de desemprego, perda de renda e aumento dos custos dos alimentos também dificultaram o acesso aos alimentos, principalmente, para a população mais vulnerável socialmente. Os processos de disponibilidade e acesso aos alimentos durante a pandemia têm impactado diretamente na escolha, preparo e consumo alimentar da população. Desta forma, medidas governamentais devem ajudar a promover a SAN das populações, por meio da criação ou expansão dos programas de proteção social, distribuição e melhoria no acesso aos alimentos, proteção de empregos e meios de subsistência e apoio aos pequenos produtores locais. Conclusão: As ações promovidas pelos governos devem garantir a SAN das populações, assegurando o acesso à alimentação adequada e saudável e objetivando a redução de impactos negativos promovidos pelo SARS-CoV-2 na condição da alimentação, saúde e nutrição da população, principalmente dos mais vulneráveisArtigo Lipídeos totais e alfa-tocoferol no leite maduro: existe relação após suplementação com vitamina E?(Demetra: Alimentação, Nutrição & Saúde, 2022) Rodrigues, Karla Danielly da Silva Ribeiro; Medeiros, Juliane Oliveira de; Rebouças, Amanda de Sousa; Dimenstein, Roberto; 0000-0002-2251-5967O consumo de lipídeos durante a lactação pode alterar a concentração de vitamina E do leite materno, provavelmente, por ambos os nutrientes possuírem caráter lipossolúvel e compartilharem vias similares de distribuição, metabolismo e ação molecular. Sabe-se que o alto consumo materno de vitamina E via suplementação altera a concentração de alfa-tocoferol no leite, porém ainda não foi estudado se essa suplementação afetaria a quantidade de lipídeos do leite. Objetivo: Avaliar a associação entre as concentrações de alfa-tocoferol e de lipídeos totais no leite materno após suplementação materna com megadose de vitamina E. Método: O presente estudo é parte de um ensaio clínico randomizado, composto por lactantes atendidas em ambulatório público de Natal-RN. O recorte foi realizado com 26 lactantes do grupo suplementado, as quais receberam dose única de 800 UI de RRR-alfa-tocoferol (588 mg) entre 30 e 90 dias pós-parto, sendo coletado leite antes e 24h após a suplementação. O consumo alimentar foi obtido pelo recordatório de 24h, o alfa-tocoferol foi analisado por cromatografia líquida de alta eficiência e a concentração de lipídeo foi determinada por crematócrito. Resultados: Todas as mulheres apresentaram consumo inadequado de vitamina E (<16mg). A concentração de alfa-tocoferol no leite aumentou de 294,8 μg/dL para 631,6 μg/dL após a suplementação (p = 0,002), e não foi encontrada relação entre o alfa-tocoferol e lipídeos totais no leite antes e após a suplementação. Conclusão: A suplementação de vitamina E não evidenciou relação entre alfa-tocoferol e lipídeos totais no leite materno.Artigo Nutritional adequacy of commercial food products targeted at 0–36-month-old children: a study in Brazil and Portugal(British Journal of Nutrition, 2022) Ribeiro, Danielly da Silva; Araújo, Célia Regina Barbosa de; Rocha, Karini Freire; Carneiro, Byanca; Morais, Inês Lança de; Breda, João; Padrão, Patrícia; Moreira, Pedro; 0000-0002-2251-5967In the context of the global childhood obesity, it is essential to monitor the nutrition value of commercial foods. A cross-sectional study (November 2018 to April 2019) aimed to evaluate the nutritional adequacy of processed/ultra-processed food products targeted at 0–36-month-old children in Portugal and in Brazil. The nutrient profiling model developed by the Pan American Health Organization was used. A total of food 171 products were assessed (123 in Portugal and forty eight in Brazil). From the fifteen available meat- or fish-based meals in Brazil, 60% exceeded the amount of Na and 100 % exceeded the target for total fat. Given the lack of specification of sugars within carbohydrates in the label of the foods in Brazil, it was not possible to calculate free sugars. In Portugal, from the seventeen fruit and vegetable purees and the six juice/smoothie/tea/drinks available, 82% and 67%, respectively, surpassed the level of free sugar, while total and saturated fat was excessive in all yogurt and yogurt-related products (n 21), 40% of biscuit/wafer/crisps (two out of five) and 13% meat- or fish-based meals (two out of sixteen). These findings demonstrate the relevance of improving the nutritional profile of some food products targeted to young children.Artigo Vitamin E concentration in human milk and associated factors: a literature review(Jornal de Pediatria, 2014) Ribeiro, Karla Danielly da Silva; Dimenstein, Roberto; Lima, Mayara Santa Rosa; 0000-0002-2251-5967Objective: To systematize information about vitamin E concentration in human milk and the variables associated with this composition in order to find possible causes of deficiency, supporting strategies to prevent it in postpartum women and infants. Source: Studies published between 2004 and 2014 that assayed alpha-tocopherol in human milk of healthy women by high performance liquid chromatography were evaluated. The keywords used were ‘‘vitamin E’’, ‘‘alpha-tocopherol’’, ‘‘milk, human’’, ‘‘lactation’’, and equivalents in Portuguese, in the BIREME, CAPES, PubMed, SciELO, ISI Web of Knowledge, HighWire Press, Ingenta, and Brazilian Digital Library of Theses and Dissertations databases. Summary of the findings: Of the 41 publications found on the subject, 25 whose full text was available and met the inclusion criteria were selected. The alpha-tocopherol concentrations found in milk were similar in most populations studied. The variable phase of lactation was shown to influence vitamin E content in milk, which is reduced until the mature milk appears. Maternal variables parity, anthropometric nutritional status, socioeconomic status, and habitual dietary intake did not appear to affect the alpha-tocopherol levels in milk. However, the influence of the variables maternal age, gestational age, biochemical nutritional status in alpha-tocopherol, and maternal supplementation with vitamin E had conflicting results in the literature. Conclusion: Alpha-tocopherol concentration in milk decreases during lactation, until the mature milk appears. To confirm the influence of some maternal and child variables on milk vitamin E content, further studies with adequate design are needed.Artigo Whey protein isolate-gelatin nanoparticles enable the water-dispersibility and potentialize the antioxidant activity of quinoa oil (Chenopodium quinoa)(PLOS ONE, 2020) Rodrigues, Danielly da Silva Ribeiro; Lira, Keith Hellen Dias da Silva; Passos, Thaís Souza; Ramalho, Heryka Myrna Maia; Vieira, Érica de Andrade; Cordeiro, Angela Maria Tribuzy de Magalhães; Maciel, Bruna Leal Lima; Damasceno, Karla Suzanne Florentino da Silva Chaves; Sousa Júnior, Francisco Canindé de; Assis, Cristiane Fernandes de; 0000-0002-2251-5967The quinoa oil presents benefits to health, but its low water dispersibility in the aqueous matrix and instability of bioactive compounds is challenging for food application. This study performed the physicochemical and chemical characterization of quinoa oil and evaluated its water dispersibility and 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scav-enging activity after nanoencapsulation in porcine gelatin and combination with whey protein isolate by emulsification O/W technique. Thus, three formulations were obtained: 1) OG–con-taining quinoa oil and porcine gelatin in aqueous phase 2; 2) OWG1—containing quinoa oil, whey protein isolate, and porcine gelatin in aqueous phase 2; and 3) OWG2—containing qui-noa oil and whey protein isolate in aqueous phase 1, and porcine gelatin in aqueous phase 2.The oil characterization showed that quinoa oil presented the predominance of linoleic acid (53.4%), and concentration of alpha and gamma-tocopherol, respectively, of 8.56 and 6.28 mg.100g-1. All formulations presented a smooth surface without depression or cracking, an average diameter between 165.77 and 529.70 nm. Fourier transform infrared spectroscopy indicated chemical interaction between the encapsulating agents and the oil in all formula-tions, being more intensified in OWG1 and OWG2. Based on this, these formulations showed higher dispersibility in aqueous solution [68% (3.48) and 71% (2.97)]. This resulted in higher antioxidant activity for OWG1 and OWG2, showing the amounts that reduces antioxidant activity by 50% equal to 5.30 (0.19) mg/mL and 5.54 (0.27) mg/mL, respectively, compared to quinoa oil [13.36 (0.28) mg/mL] (p < 0.05). Thus, quinoa oil nanoencapsulation proved to be an efficient alternative to enable water-dispersibility and enhance antioxidant activity, increasing its potential for application in the food industry.