CCS - DACT- Artigos publicados em periódicos

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Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome
(Elsevier, 2016-01) Sá, Joceline Cassia Ferezini de; Costa, Eduardo Caldas; Silva, Ester da; Tamburús, Nayara Y.; Porta, Alberto; Medeiros, Leany F.; Lemos, Telma Maria Araujo Moura Lemos; Soares, Elvira M. M.; Azevedo, George Dantas de
Background: this study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods: thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R–R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results: the exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p b 0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p b 0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p b 0.05). All parameters remained unchanged in the control group. Conclusions: aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients
Aerobic training improves quality of life in women with Polycystic Ovary Syndrome
(Lippincott, Williams & Wilkins, 2018-07) Costa, Eduardo Caldas; Sá, Joceline Cássia Ferezini de; Stepto, Nigel Keith; Costa, Ingrid Bezerra Barbosa; Farias Junior, Luiz Fernando; Moreira, Simone da Nóbrega Tomaz; Soares, Elvira Maria Mafaldo; Lemos, Telma Maria Araujo Moura; Browne, Rodrigo Alberto Vieira; Azevedo, George Dantas de
Purpose: to investigate the effects of a supervised aerobic exercise training intervention on health-related quality of life (HRQL), cardiorespiratory fitness, cardiometabolic profile, and affective response in overweight/obese women with polycystic ovary syndrome (PCOS). Methods: twenty-seven overweight/obese inactive women with PCOS (body mass index, ≥ 25 kg·m−2; age 18 to 34 yr) were allocated into an exercise group (n = 14) and a control group (n = 13). Progressive aerobic exercise training was performed three times per week (~150 min·wk−1) over 16 wk. Cardiorespiratory fitness, HRQL, and cardiometabolic profile were evaluated before and after the intervention. Affective response (i.e., feeling of pleasure/displeasure) was evaluated during the exercise sessions. Results: the exercise group improved 21% ± 12% of cardiorespiratory fitness (P < 0.001) and HRQL in the following domains: physical functioning, general health, and mental health (P < 0.05). Moreover, the exercise group decreased body mass index, waist circumference, systolic and diastolic blood pressure, and total cholesterol level (P < 0.05). The affective response varied from “good” to “fairly good” (i.e., positive affective response) in an exercise intensity-dependent manner during the exercise training sessions. Conclusions: progressive aerobic exercise training improved HRQL, cardiorespiratory fitness, and cardiometabolic profile of overweight/obese women with PCOS. Moreover, the participants reported the exercise training sessions as pleasant over the intervention. These results reinforce the importance of supervised exercise training as a therapeutic approach for overweight/obese women with PCOS
Affect-regulated exercise: an alternative approach for lifestyle modification in overweight/obese women with polycystic ovary syndrome
(Taylor and Francis, 2015-09-25) Costa, Eduardo Caldas; Sá, Joceline Cássia Ferezini de; Costa, Ingrid Bezerra Barbosa; Meireles, Rodrigo da Silva Rosa Veleda; Lemos, Telma Maria Araújo Moura; Elsangedy, Hassan Mohamed; Krinski, Kleverton; Azevedo, George Dantas de
Objective: affect-regulated exercise (‘‘ARE’’) is an alternative approach to guide exercise intensity based on feeling of pleasure. The aim of this study was to analyze if overweight/obese women with polycystic ovary syndrome (PCOS) meet the American College of Sports Medicine (ACSM) recommendation regarding to exercise intensity to improve health status during a single bout of ‘‘ARE". Methods: a sample of 14 overweight/obese women with PCOS (18–34 years) performed a single bout of ‘‘ARE’’ (40 min of aerobic exercise on outdoor track). The Feeling Scale (FS) was used to guide ‘‘ARE’’ intensity/pace maintaining an affective valence between ‘‘good’’ and ‘‘very good’’ during all time. Heart rate (HR), speed, % of HR at first and second ventilatory threshold (VT1 and VT2) and time spent at moderate (64–76% of HRmax) and vigorous (77–95% of HRmax) intensity during ‘‘ARE’’ were measured with a global positioning system (GPS) device. Results: volunteers exercised at 73% (68–78%) of HRmax, 5.8 (5.2–6.2) km/h, 93.4% of HR at VT1 (89.3–98.2) and 80.5% of HR at VT2 (75.3–84.6) and spent 480% of time at moderate intensity. Conclusions: overweight/obese women with PCOS met the ACSM recommendation regarding exercise intensity to improve health status when exercised between ‘‘good’’ and ‘‘very good’’ of FS. Thus, ‘‘ARE’’ may be an interesting approach to be used in clinical practice regarding to exercise prescription and/or physical activity advice
Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents
(Sociedade Brasileira de Endocrinologia e Metabologia, 2016-06) Melo, Elza Maria Fernandes Seabra de; Azevedo, George Dantas de; Silva, João Batista da; Lemos, Telma Maria Araujo Moura; Maranhão, Técia M. O.; Freitas, Ana Karla Monteiro Santana de Oliveira; Spyrides, Maria H.; Costa, Eduardo Caldas
Objective: To assess the prevalence and clustering patterns of cardiometabolic risk factors among low-income, female adolescents. Materials and methods: Cross-sectional study involving 196 students of public schools (11-19 years old). The following risk factors were considered in the analysis: excess weight, central obesity, dyslipidemia, high blood pressure, and high fasting glucose. The ratio between observed and expected prevalence and its confidence interval were used to identify clustering of risk factors that exceeded expected prevalence in the population. Results: The most prevalent risk factors were dyslipidemia (70.9%), and central obesity (39.8%), followed by excess weight (29.6%), and high blood pressure (12.8%). A total of 42.9% of adolescents had two or more risk factors, and 24% had three or more. Excess weight, central obesity, and dyslipidemia were common risk factors in the clustering patterns that showed higher-than-expected prevalence. Conclusions: Clustering of risk factors (≥ two factors) among the adolescents showed considerable prevalence, and there was a non-casual coexistence of excess weight, central obesity, and dyslipidemia (mainly low HDL-cholesterol).
Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome
(Karger Publishers, 2016-04-14) Soares, Nayara Pereira; Santos, Ana Celly Souza dos; Costa, Eduardo Caldas; Azevedo, George Dantas de; Damasceno, Débora Cristina; Fayh, Ana Paula Trussardi; Lemos, Telma Maria Araujo Moura
Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients
Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography
(Hindawi, 2015-02-11) Souza Júnior, José Edvan de; Garcia, Carlos Alexandre de Amorim; Soares, Elvira Maria Mafaldo; Maranhão, Técia Maria Oliveira; Lemos, Telma Maria Araujo Moura; Azevedo, George Dantas de
Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (𝑃 = 0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (𝑃 < 0.05). Both the presence of obesity associated with insulin resistance (𝑃 = 0.037) and glucose intolerance (𝑃 = 0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (𝑃 < 0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (𝑃 = 0.034). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS
Prevalência da síndrome metabólica nos estágios pubertários de escolares do sexo feminino
(Universidad Nacional de Colombia, 2016-06-03) Silva, João Batista da; Melo, Elza Maria Fernandes Seabra de; Micussi, Maria Thereza Albuquerque Barbosa Cabral; Azevedo, George Dantas de; Lemos, Telma Maria Araujo Moura; Spyrides, Maria H.; Arrais, Ricardo Fernando; Maranhão, Técia M.
Objetivo Analisar a prevalência da síndrome metabólica (SM) nos estágios pubertários de escolares do sexo feminino. Métodos Estudo transversal com 449 escolares, entre oito e 18 anos, estratificadas nos estágios pubertário, índice de massa corporal (IMC) e percentual de gordura (%G). A SM foi classificada pela International Diabetes Federation. A análise feita pela distribuição de frequências, intervalos de confiança (95 %), Qui-quadrado e razão de chance para associações. Resultados A prevalência de SM foi 3,3 % (IC:2 %-5 %), sendo 2,5 % (IC:0,1 %-5%) no púbere e 7,9 % (IC:3,2 %-12,6 %) no pós-púberes, com associação significante destes com a SM (X2=5,2 [p<0,02]). A razão de chance aponta meninas pós-púberes (3,3 [IC:1,2-5]) e obesas (2,1 [CI:2-2,2]) mais propensas à SM, indicando associação linear significante do IMC com o desfecho (X2=29,4 [p<0,001]). Púberes menos de 10 anos com SM apresentaram maiores %G. Os componentes prevalentes foram: circunferência da cintura alterada (27,2 % [IC23 %-31 %]) e colesterol HDL baixo (39,6 % [IC35 %-44 %]) e prevalência da hipertensão sistêmica nas pós-púberes. Conclusões A SM inicia-se no estágio púbere, com prevalência no pós-púbere, sendo o excesso de gordura o desencadeador nas menores de 10 anos. Estratégias de prevenção são necessárias à população de crianças e adolescentes.
Revisiting an unsolved problem – impact of SLICC criteria on the risk of metabolic syndrome
(SAGE Publications, 2016-07-11) Lima Júnior, J. C.; Lemos, Telma Maria Araujo Moura; Azevedo, George Dantas de; Vilar, Maria José Pereira
As with mostprevious studies on the prevalence of metabolicsyndrome (MetS) in systemic lupus erythematosus(SLE), in which the prevalence varies greatly, itwas found to be always greater than in non-lupus patients. MetS, a bundle of cardiovascular risk factors, is highly prevalent and associated with increased rate of cardiovascular events and death. Apart from these risk factors, MetS is closely correlated with inflammation. Not only are they related to each other, but the inflammatory burst also precedes the MetS. Was evaluated the influence of SLICC criteria and other disease-specific factors in the presentation of MetS. In order to evaluate these factors, It was conducted a cross-sectional pilot study with 59 women with SLE according to the American College Rheumatology (ACR) criteria at the rheumatology out patient clinic. Individuals with SLE had a higher prevalence of MetS (30.5%) than controls (20.5%), as shown previously. Despite this higher prevalence, there was no si-nificant association between the presence of SLE and whether individuals had MetS or not(p¼0.117). Via a binary logistic regression, was evaluated the chance of specific factors associated with SLE predicting the presence of MetS. No significant association was detected between MetS and any SLE specific factors.
The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome
(Taylor and Francis, 2015-11-06) Santos, Ana Celly Souza dos; Soares, Nayara Pereira; Costa, Eduardo Caldas; Sá, Joceline Cássia Ferrezini de; Azevedo, George Dantas de; Lemos, Telma Maria Araújo Moura
Objective: to evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI). Methods: tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n¼12), II (non-eutrophic without PCOS, n¼10), III (eutrophic with PCOS, n¼8) and IV (eutrophic without PCOS, n¼10) being non-eutrophic, the overweight and obese women with BMI425 kg/m2 and eutrophic women with BMI524.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR. Results: PCOS patients showed increased levels of CRP (p50.01) and HOMA-IR (p50.01). When divided by BMI, both non-eutrophic and eutrophic PCOS showed increased CRP levels (p50.01) and HOMA-IR (p50.01). There were no differences in TNF-a and IL-6 levels between groups. Conclusion: in the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass

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