Navegando por Autor "Pedrosa, Lúcia Fátima Campos"
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Artigo Factors associated with inflamm-aging in institutionalized older people(Scientific Reports, 2021-09) Evangelista, Karine Cavalcanti Maurício de Sena; Oliveira Neto, Leônidas de; Tavares, Vagner Deuel de Oliveira; Agrícola, Pedro Moraes Dutra; Oliveira, Larissa Praça de; Sales, Márcia Cristina; Gomes, Igor Conterato; Coelho, Nicole Leite Galvão; Pedrosa, Lúcia Fátima Campos; Lima, Kenio CostaThe increase in infammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for infammation. Despite the high infammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with infamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their infammatory state. Analysis anthropometric, biochemical, sociodemographic, and healthrelated variables was carried out. In sequence, an ordinal logistic regression was performed for a confdence level of 95% in those variables with p< 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with infammaging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of infammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥80 years old) had an 84.9% chance of presenting infamm-aging in relation to non-long-lived older people (<80 years). The association between biochemical markers and infamm-aging demonstrates a relationship between endothelial injury and the infammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death