Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas

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Coordenado pela Sociedade Brasileira de Fisiologia (SBFis). A UFRN é uma das unidades associadas e realiza pesquisas nas temáticas Neurofisiologia e Comportamento, Regulação da Função Respiratória, Fisiologia do Sistema Cardiovascular, Ensino de Fisiologia e Divulgação Científica e, Fisiologia do Exercício Físico.

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    Master Thesis
    Papel do sistema Nociceptina/Orfanina FQ - receptor NOP hipocampal no processamento da memória de reconhecimento de objetos
    (Universidade Federal do Rio Grande do Norte, 2025-08-29) Santos, Lucas Denylson Ribeiro Farias; Rossato, Janine Inez; https://orcid.org/0000-0002-7980-5842; http://lattes.cnpq.br/8136970112250481; http://lattes.cnpq.br/0075219136937638; Gavioli, Elaine Cristina; http://lattes.cnpq.br/1759328747578795; Moraes, Grace Schenatto Pereira; http://lattes.cnpq.br/1884100217996439
    Recognition memory refers to the ability to identify previously encountered events, objects, or individuals. It is a crucial cognitive function, allowing individuals to use past experiences to adapt to future situations. The hippocampus plays a central role in encoding new events and comparing them with stored experiences, enabling necessary behavioral adjustments in response to changes. The importance of recognition memory becomes more evident when it fails, a common occurrence in amnesic syndromes. The novel object recognition (NOR) task is widely used to study object recognition memory (ORM) in rodents. The endogenous peptide nociceptin, also called orphanin FQ (N/OFQ), participates in the regulation of cognition. Its receptors, NOP, are present in various brain regions, with particularly high expression in the hippocampus. However, the involvement of hippocampal NOP receptors in different phases of ORM processing is poorly studied and the findings are ambiguous. Our results indicate that intra-CA1 infusion of N/OFQ before, but not immediately after NOR task training, impairs in a dose-dependent manner, ORM in adult male Wistar rats. This amnestic effect is reversed by the co-infusion of the NOP antagonist, UFP-101. N/OFQ infusion does not affect ORM expression. Taken together, our results suggest that N/OFQ infusion disrupts ORM acquisition, but not its consolidation or retrieval, and that the amnesic effect is mediated by the activation of hippocampal NOP receptor signaling.
  • Doutorado em Ciências Fisiológicas
  • Mestrado em Ciências Fisiológicas
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