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Title: Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
Authors: Barbosa, Vanessa Santos de Arruda
Holanda, Cecília Maria de Carvalho Xavier
Silva, Roseane Pereira da
Oliveira, Daniel Pereira de
Silva Júnior, Maurício Ferreira da
Oliveira, Elias Herculano de
Spyrides, Maria Helena Constantino
Medeiros, Aldo Cunha
Keywords: Antiparasite;Radiopharmaceutical;Technetium-99m;Benznidazole;Biodistribution;Trypanosoma cruzi
Issue Date: 2008
Citation: BARBOSA, Vanessa Santos de Arruda ; HOLANDA, Cecília Maria de Carvalho Xavier ; SILVA, Roseane Pereira da ; OLIVEIRA, Daniel Pereira de ; SILVA JÚNIOR, Maurício Ferreira da ; OLIVEIRA, Elias Herculano de ; SPYRIDES, Maria Helena Constantino ; MEDEIROS, Aldo Cunha. Effect of tripanosomicide benznidazole (Rochagan ) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats. Brazilian Archives of Biology and Technology , v. 51, p. 175-180, 2008. Disponível em: <>. Acesso em: 19 set. 2013.
Abstract: Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas’ disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole
ISSN: 1516-8913
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos

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