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Title: Influence of Splenectomy on the Biodistribution of Technetium-99m Dimercaptosuccinic Acid (99mTc-DMSA) in Rats
Authors: Açucena, Maria Kadja Meneses Torres
Pereira, Kércia Regina Santos Gomes
Villarim Neto, Arthur
Rêgo, Amália Cínthia Meneses
Bernardo Filho, Mário
Azevedo, Ítalo Medeiros
Araújo Filho, Irami
Medeiros, Aldo Cunha
Keywords: Splenectomy;Biodistribution;Technetium;Rats
Issue Date: 2008
Citation: AÇUCENA, Maria Kadja Meneses Torres ; PEREIRA, Kércia Regina Santos Gomes ; VILLARIM NETO, Arthur ; RÊGO, Amália Cínthia Meneses ; BERNARDO FILHO, Mario ; AZEVEDO, Ítalo Medeiros ; ARAÚJO FILHO, Irami ; MEDEIROS, Aldo Cunha. Influence of splenectomy on the biodistribution of technetium-99m dimercaptosuccinic acid (99mTc-DMSA) in rats. Brazilian Archives of Biology and Technology , v. 51, p. 197-202, 2008.Disponível em: <> Acesso em: 09 out. 2013.
Abstract: This study aimed to evaluate if the splenectomy alters the biodistribution of 99mTc-DMSA and renal function in Wistar rats. The animals were separated in the groups: splenectomy (n = 6) and control (n = 6). After splenectomy (15 days), the administration of 0.1ml of 99mTc-DMSA IV (0.48 MBq) was carried out. Thirty minutes later, kidney, heart, lung, thyroid, stomach, bladder and femur and samples of blood were isolated. The organs were weighed, counted and the percentage of radioactivity -g (%ATI-g) determined. Serum urea and creatinine, hematocrit, leukocytes and platelets were measured. Statistics by t test (p<0.05) was done. There was a significant reduction in %ATI-g in kidney and blood (p<0.05) of splenectomized animals, a significant increase (p<0.05) of urea (88.8 ± 18.6 mg-dL) and creatinine (0.56 ± 0.08 mg-dL), compared to the controls (51.5±1.6, 0.37±0.02mg-dL, respectively), as well as increase in platelets and leucocytes, and hematocrit reduction. The analysis of the results indicates that in rats, splenectomy seems to alter the renal function and the uptake of 99mTc-DMSA
ISSN: 1516-8913
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos

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