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Title: Biodistribution of the Radiopharmaceutical Technetium- 99m-Sodium Phytate in Rats After Splenectomy
Authors: Pereira, Kércia Regina Santos Gomes
Açucena, Maria Kadja Meneses Torres
Villarim Neto, Arthur
Rêgo, Amália Cínthia Meneses
Bernardo Filho, Mário
Azevedo, Ítalo Medeiros
Araújo Filho, Irami
Medeiros, Aldo Cunha
Keywords: Splenectomy;Sodium phytate;Biodistribution;Liver
Issue Date: 2008
Citation: PEREIRA, Kércia Regina Santos Gomes ; AÇUCENA, Maria Kadja Meneses Torres ; VILLARIM NETO, Arthur ; RÊGO, Amália Cínthia Meneses; BERNARDO FILHO, Mário; AZEVEDO, Ítalo Medeiros; ARAÚJO FILHO, Irami; MEDEIROS, Aldo Cunha. Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy. Brazilian Archives of Biology and Technology , v. 51, p. 203-207, 2008. Disponível em: <> Acesso em: 09 out. 2013.
Abstract: Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI-g) was determined by a Wizard Perkin-Elme gama counter. The ATI%-g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity
ISSN: 1516-8913
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos

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