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Title: Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences
Authors: Costa, Marcos Romualdo
Ulrich Müller
Keywords: cerebral cortex;developmen;excitatory neurons;progenitor diversity;neuronal specification
Issue Date: 12-Jan-2015
Citation: COSTA, Marcos R.; MÜLLER, Ulrich. Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences. Fontiers in Celular Neuroscience. v.8, jan. 2015. doi: 10.3389/fncel.2014.00449.
Abstract: The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate.
ISSN: 1662-5102
Appears in Collections:ICe - Artigos publicados em periódicos

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