Please use this identifier to cite or link to this item:
|Title:||State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation|
|Authors:||Rossato, Janine I.|
Köhler, Cristiano A.
Lima, Ramón H.
Bevilaqua, Lia R.M.
|Keywords:||Object recognition memory;Retrieval;Hippocampus;Protein synthesis;Gene expression|
|Citation:||Rossato, J. et. al. (2015). State-dependent effect of dopamine D₁/D₅ receptors inactivation on memory destabilization and reconsolidation. Behav Brain Res. 2015 May 15;285:194-9. doi: 10.1016/j.bbr.2014.09.009. Epub 2014 Sep 16.|
|Abstract:||Object recognition memories (ORM) can incorporate new information upon reactivation. This update initially involves destabilization ofthe original memory, which is followed by restabilization ofthe upgraded engram through a reconsolidation process that requires gene expression and protein synthesis in the hippocampus. We found that when given in dorsal CA1 either immediately after training or 15 min before ORM reactivation in the presence of a novel object, the dopamine D1/D5 receptor antagonist SCH23390 did not affect ORM consolidation, expression or retention but impeded the amnesia caused by the postretrieval administration of the mRNA synthesis inhibitor -amanitin or the protein synthesis blocker anisomycin. This anti-amnesic effect was not observed when SCH23390 was given immediately after training and again 15 min before memory reactivation. Our results demonstrate that hippocampal D1/D5 receptors are not needed for formation, retrieval or post-retrieval restabilization of the ORM trace but are essential for its destabilization when reactivation occurs together with the incorporation of new information into the original memory. Importantly, they also suggest that reenactment of the animal’s post-learning neurochemical milieu at the moment of memory reactivation can be a boundary condition for reconsolidation.|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
Files in This Item:
|JanineRossato_ICE_State-dependent2015.pdf||Artigo completo||1,26 MB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.