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https://repositorio.ufrn.br/handle/123456789/21788| Título: | Immunohistochemical expression of matrix metalloproteinases 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor |
| Autor(es): | Ribeiro, Betania Fachetti Araújo, Cristina Ruan Ferreira de Santos, Bruna Rafaela Martins dos Freitas, Roseana de Almeida |
| Palavras-chave: | Immunohistochemical;Matrix Metalloproteinases |
| Data do documento: | 2011 |
| Referência: | RIBEIRO, Betania Fachetti et al. Immunohistochemical expression of matrix metalloproteinases 1, 2, 7, 9, and 26 in the calcifying cystic odontogenic tumor. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 112, n. 5, p. 609-615, 2011. |
| Resumo: | OBJECTIVE: The aim was to evaluate immunoexpression of matrix metalloproteinases (MMPs) 1, 2, 7, 9, and 26 in calcifying cystic odontogenic tumor (CCOT). STUDY DESIGN: Ten cases of CCOT were assessed by immunohistochemical expression of MMPs 1, 2, 7, 9, and 26 in the parenchyma and stroma. Metalloproteinase immunoexpressions and their distribution pattern were semiquantitatively scored. RESULTS: MMPs were expressed in the parenchyma and stroma in all cases of CCOT. Regarding the percentage of immunostained parenchymal cells, MMPs 1, 7, and 9 showed score 2 in 100% of cases. For MMP-2, there was a predominance of score 0 (90%), whereas for MMP-26 immunostaining was varied. CONCLUSIONS: The staining of these metalloproteinases, with the exception of MMP-2, suggests their contribution to tumor growth and expansion. The presence of these metalloproteinases in stromal cells reveals the active participation of these cells in the degradation of the extracellular matrix, contributing to the growth of the tumor studied. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/21788 |
| Aparece nas coleções: | CCS - DOD - Artigos publicados em periódicos |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| ImmunohistochemicalExpressionMatrix_Ribeiro_2011.pdf | https://www.ncbi.nlm.nih.gov/pubmed/21903428 | 2,3 MB | Adobe PDF | Visualizar/Abrir |
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