1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DOD - Departamento de Odontologia
4. CCS - DOD - Artigos publicados em periódicos

Title:	Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma
Authors:	Freitas, Valéria Souza Santos, Pedro Paulo de Andrade Freitas, Roseana de Almeida Pinto, Leão Pereira Souza, Lelia Batista de
Keywords:	Mast cells;Matrix metalloproteinase 9
Issue Date:	2011
Citation:	FREITAS, Valéria Souza et al. Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 112, n. 3, p. 342-348, 2011.
Portuguese Abstract:	Objectives The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). Study design Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniques. Results Tryptase+ and c-Kit+ MC densities were significantly higher in SCCs than in ACs and control samples (P < .001). However, no significant difference was found when comparing tryptase+ and c-Kit+ MC densities between ACs and control samples (P values .185 and .516, respectively). MMP-9 was strongly expressed in SCCs and moderately expressed in ACs and control samples. A highly significant association was found between tryptase+ MC density and the expression of MMP-9 (P < .001). Conclusions The increase in MC density associated with the strong expression of MMP-9 may favor SCC progression.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/21798
Appears in Collections:	CCS - DOD - Artigos publicados em periódicos

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