Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/21800
Title: Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors
Authors: Medeiros, Ana Miryam Costa de
Nonaka, Cassiano Francisco Weege
Galvão, Hebel Cavalcanti
Souza, Lelia Batista de
Freitas, Roseana de Almeida
Keywords: Ameloblastoma;Adenomatoid odontogenic tumor;Fibronectin;Tenascin;Collagen
Issue Date: 2010
Citation: MEDEIROS, Ana Miryam Costa et al. Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors. European Archives of Oto-Rhino-Laryngology, v. 267, n. 2, p. 303-310, 2010.
Portuguese Abstract: This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/21800
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

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