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Title: Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors
Authors: Freitas, Valéria Souza
Araújo, Cristina Ruan Ferreira de
Alves, Pollianna Muniz
Souza, Lelia Batista de
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Keywords: Immunohistochemistry;ameloblastoma;Adenomatoid Tumor;MMP-7;MMP-26
Issue Date: 2009
Citation: FREITAS, Valéria Souza et al. Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 108, n. 3, p. 417-424, 2009.
Portuguese Abstract: OBJECTIVE: The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs). STUDY DESIGN: Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 and -26 in the epithelium and stroma. RESULTS: There was no statistically significant difference in MMP-7 and -26 expression between the epithelium of ameloblastomas (P = .50) and AOTs (P = .90). Stromal staining for MMP-7 was evident in all cases. For MMP-26, stromal staining was observed in 65% of ameloblastomas and 50% of AOTs, and this difference was not statistically significant (P = .69). CONCLUSION: The marked expression of these matrilysins suggests their role in the process of tissue remodeling and growth in the studied tumors, but it does not relate to the their distinct patterns of aggressiveness.
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