Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/21848
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMonteiro, Bárbara Vanessa de Brito-
dc.contributor.authorCavalcante, Roberta Barroso-
dc.contributor.authorNogueira, Renato Luiz Maia-
dc.contributor.authorMiguel, Marcia Cristina da Costa-
dc.contributor.authorNonaka, Cassiano Francisco Weege-
dc.contributor.authorSilveira, Ericka Janine Dantas da-
dc.date.accessioned2017-02-02T10:59:51Z-
dc.date.available2017-02-02T10:59:51Z-
dc.date.issued2015-
dc.identifier.citationMONTEIRO, B. V. B.. Participation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumors. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 120, n. 1, p. 52-57, 2015.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/21848-
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEtiologypt_BR
dc.subjecthMLH1pt_BR
dc.subjectp63pt_BR
dc.subjectMDM2pt_BR
dc.titleParticipation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumorspt_BR
dc.typearticlept_BR
dc.description.resumoObjectives To evaluate the expression of hMLH1, p63, and MDM2 in Gorlin syndrome–associated keratocystic odontogenic tumors (SKOTs) and nonsyndromic keratocystic odontogenic tumors (NSKOTs). Study Design Seventeen primary NSKOTs, 17 SKOTs, and 8 recurrent NSKOTs were analyzed by using immunohistochemistry. Results No significant differences in the hMLH1, p63, or MDM2 labeling indices were observed between groups (P = .398; P = .232; P = .426, respectively). Higher hMLH1 immunoexpression was found in the basal layer of primary NSKOTs. Most KOTs exhibited p63 immunoexpression in the upper layers of the epithelium. MDM2 immunoexpression was observed in the upper epithelial layers of SKOTs and recurrent NSKOTs. Conclusion It was not possible to correlate the immunoexpression of hMLH1, p63, and MDM2 in SKOTs and primary and recurrent NSKOTs, suggesting that these proteins exert independent effects on the development of these groups of tumors.pt_BR
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
Participation of hMLH1, p63, and MDM2_2015.pdfhttp://www.sciencedirect.com/science/article/pii/S22124403150061361.69 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.