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dc.contributor.authorBitencourt, Mariana A.O.-
dc.contributor.authorSilva, Hylarina M.D.-
dc.contributor.authorAbílio, Gisely M.F.-
dc.contributor.authorMiranda, George E.C.-
dc.contributor.authorMoura, Adolpho M.A.-
dc.contributor.authorAraújo-Júnior, João X. de-
dc.contributor.authorSilveira, Ericka Janine Dantas da-
dc.contributor.authorSantos, Barbara V.O.-
dc.contributor.authorSouto, Janeusa T.-
dc.identifier.citationBITENCOURT, M. A. O. et al. Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis. Revista Brasileira de Farmacognosia, v. 25, n. 6, p. 677-682, 2015.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCaulerpa mexicanapt_BR
dc.subjectGreen algaept_BR
dc.subjectUlcerative colitispt_BR
dc.subjectTissue damagept_BR
dc.titleAnti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitispt_BR
dc.description.resumoInflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, are characterized by chronic and relapsed gut inflammation. Caulerpa mexicana is a type of green marine algae that can be found in tropical areas, such as the Brazilian Coastland. These macrophytes exhibit in vitro and in vivo anti-inflammatory properties such as the ability to reduce both cell migration to different sites and edema formation induced by chemical irritants. The aim of this study was to examine the effect of the C. mexicana methanolic extract on the treatment of colitis induced by dextran sodium sulfate. Acute experimental colitis was induced in BALB/c mice by treatment with 3% dextran sodium sulfate orally for 14 days. During this 14-day period, C. mexicana methanolic extract (2 mg/kg/day) was given intravenously on alternate days. Treatment with the methanolic extract significantly attenuated body weight loss and severe clinical symptoms. This was associated with a remarkable amelioration of colonic architecture disruption and a significant reduction in pro-inflammatory cytokine production. These results suggest that the anti-inflammatory action of C. mexicana methanolic extract on colorectal sites may be a useful therapeutic approach for inflammatory bowel diseases.pt_BR
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