Please use this identifier to cite or link to this item:
|Title:||On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus|
Tort, Adriano Bretanha Lopes
|Portuguese Abstract:||Phase-amplitude coupling between theta and multiple gamma sub-bands is a hallmark of hippocampal activity and believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit phase-phase coupling, or n:m phase-locking, suggesting an important mechanism of neuronal coding that has long received theoretical support. However, by analyzing simulated and actual LFPs, here we question the existence of theta-gamma phase-phase coupling in the rat hippocampus. We show that the quasi-linear phase shifts introduced by filtering lead to spurious coupling levels in both white noise and hippocampal LFPs, which highly depend on epoch length, and that significant coupling may be falsely detected when employing improper surrogate methods. We also show that waveform asymmetry and frequency harmonics may generate artifactual n:m phase-locking. Studies investigating phase-phase coupling should rely on appropriate statistical controls and be aware of confounding factors; otherwise, they could easily fall into analysis pitfalls.|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
Files in This Item:
|On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus.pdf||AdrianoTort_ICe_On cross-frequency_2016||4,11 MB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.