Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorOsório, Flávia de L.-
dc.contributor.authorSanches, Rafael F.-
dc.contributor.authorMacedo, Ligia R.-
dc.contributor.authorSantos, Rafael G. dos-
dc.contributor.authorMaia-de-Oliveira, João P.-
dc.contributor.authorWichert-Ana, Lauro-
dc.contributor.authorAraujo, Draulio B. de-
dc.contributor.authorRiba, Jordi-
dc.contributor.authorCrippa, José A.-
dc.contributor.authorHallak, Jaime E.-
dc.identifier.citationOSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectpsychedelic agentspt_BR
dc.subjectmonoamine oxidase inhibitorspt_BR
dc.subjectmonoamine oxidase inhibitorspt_BR
dc.subjecttherapeutic usept_BR
dc.titleAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary reportpt_BR
dc.description.resumoObjectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.pt_BR
Appears in Collections:ICe - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression.pdfDraulioAraujo_ICe_Antidepressant effects_2015194.26 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.