Use este identificador para citar ou linkar para este item:
https://repositorio.ufrn.br/handle/123456789/23119
Título: | Minocycline treatment reduces white matter damage after excitotoxic striatal injury |
Autor(es): | Guimarães, Joanilson S. Freire, Marco Aurelio M. Lima, Rafael R. Picanço-Diniz, Cristovam W. Pereira, Antonio Gomes-Leal, Walace |
Palavras-chave: | Excitotoxicity;Neurodegeneration;Oligodendrocyte;Myelin;White matter;Striatum |
Data do documento: | 2010 |
Resumo: | We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon. |
URI: | https://repositorio.ufrn.br/jspui/handle/123456789/23119 |
ISSN: | 0006-8993 |
Aparece nas coleções: | ICe - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
minocycline treatment.pdf | Artigo completo | 3,09 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.