1. Universidade Federal do Rio Grande do Norte
2. Instituto do Cérebro
3. ICe - Artigos publicados em periódicos

Title:	Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
Authors:	Robson Scheffer-Teixeira Hindiael Belchior Fábio V. Caixeta Bryan C. Souza Ribeiro, Sidarta Tollendal Gomes Tort, Adriano Bretanha Lopes
Keywords:	amplitude modulation;cross-frequency coupling;gamma;hippocampal oscillations;local field potential
Issue Date:	Oct-2012
Portuguese Abstract:	It was recently proposed that fast gamma oscillations (60--150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ~80 Hz and a faster oscillation centered at ~140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-- moleculare, while theta-140 Hz coupling is strongest at stratum oriens--alveus. This laminar profile suggests that the ~80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ~140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ~140 Hz oscillation differs from sharp wave--associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta--associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/23282
ISSN:	1047-3211
Appears in Collections:	ICe - Artigos publicados em periódicos

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