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Title: On the Role of Retrosplenial Cortex in Long-Lasting Memory Storage
Authors: Katche, Cynthia
Dorman, Guido
Gonzalez, Carolina
Kramar, Cecilia P.
Slipczuk, Leandro
Rossato, Janine I.
Cammarota, Martín Pablo
Medina, Jorge H.
Keywords: protein synthesis;c-Fos;hippocampus;memory persistence;dopamine
Issue Date: 2013
Portuguese Abstract: The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/ D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.
ISSN: 1050-9631
Appears in Collections:ICe - Artigos publicados em periódicos

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