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Title: Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
Authors: Gonzalez, Carolina
Kramar, Cecilia
Garagoli, Fernando
Rossato, Janine I.
Weisstaub, Noelia
Cammarota, Martín Pablo
Medina, Jorge H.
Keywords: Medial prefrontal cortex;Hippocampus;Memory consolidation;Memory retrieval;Inhibitory avoidance
Issue Date: 2013
Portuguese Abstract: The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
Appears in Collections:ICe - Artigos publicados em periódicos

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