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Title: Nicotine modulates the long-lasting storage of fear memory
Authors: Lima, Ramón H.
Radiske, Andressa
Köhler, Cristiano A.
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Müller
Rossato, Janine I.
Medina, Jorge H.
Cammarota, Martín Pablo
Keywords: hippocampus;ventral tegmental area;long-term memory;Nicotinic acetylcholine receptors
Issue Date: 2013
Portuguese Abstract: Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.
Appears in Collections:ICe - Artigos publicados em periódicos

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