Please use this identifier to cite or link to this item:
https://repositorio.ufrn.br/handle/123456789/23337| Title: | Nicotine modulates the long-lasting storage of fear memory |
| Authors: | Lima, Ramón H. Radiske, Andressa Köhler, Cristiano A. Gonzalez, Maria Carolina Bevilaqua, Lia Rejane Müller Rossato, Janine I. Medina, Jorge H. Cammarota, Martín Pablo |
| Keywords: | hippocampus;ventral tegmental area;long-term memory;Nicotinic acetylcholine receptors |
| Issue Date: | 2013 |
| Portuguese Abstract: | Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/23337 |
| Appears in Collections: | ICe - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nicotine modulates the long-lasting storage.pdf | MartínCammarota_ICe_Nicotine modulates_2013 | 475,2 kB | Adobe PDF |  View/Open |
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