Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice

França, Arthur S.C.; Muratori, Larissa; Nascimento, George Carlos do; Pereira, Catia Mendes; Ribeiro, Sidarta Tollendal Gomes; Soares, Bruno Lobão

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Campo DC	Valor	Idioma
dc.contributor.author	França, Arthur S.C.	-
dc.contributor.author	Muratori, Larissa	-
dc.contributor.author	Nascimento, George Carlos do	-
dc.contributor.author	Pereira, Catia Mendes	-
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes	-
dc.contributor.author	Soares, Bruno Lobão	-
dc.date.accessioned	2017-06-02T11:31:54Z	-
dc.date.available	2017-06-02T11:31:54Z	-
dc.date.issued	2016	-
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23367	-
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	DAT-KO	pt_BR
dc.subject	Dopamine	pt_BR
dc.subject	Haloperidol	pt_BR
dc.subject	Heterozygous	pt_BR
dc.subject	Object recognition	pt_BR
dc.title	Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice	pt_BR
dc.type	article	pt_BR
dc.identifier.doi	10.1016/j.bbr.2016.04.009	-
dc.description.resumo	Genetically-modified mice without the dopamine transporter (DAT) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. Here we investigated the capacity for object recognition in mildly hyperdopaminergic mice heterozygous for DAT (DAT +/-), with synaptic dopaminergic levels situated between those shown by DAT -/- homozygous and wild-type (WT) mice. We used a classical dopamine D2 antagonist, haloperidol, to modulate the levels of dopaminergic transmission in a dose-dependent manner, before or after exploring novel objects. In comparison with WT mice, DAT +/- mice showed a deficit in object recognition upon subsequent testing 24h later. This deficit was compensated by a single 0.05mg/kg haloperidol injection 30min before training. In all mice, a 0.3mg/kg haloperidol injected immediately after training impaired object recognition. The results indicate that a mild enhancement of dopaminergic levels can be detrimental to object recognition, and that this deficit can be rescued by a low dose of a D2 dopamine receptor antagonist. This suggests that novel object recognition is optimal at intermediate levels of D2 receptor activity.	pt_BR
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