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Title: Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis
Authors: Araújo Júnior, Raimundo Fernandes de
Souza, Tatiana Oliveira
Moura, Lígia Moreno de
Torres, Kerginaldo Paulo
Souza, Lélia Batista de
Alves, Maria do Socorro Costa Feitosa
Rocha, Hugo Oliveira
Araújo, Aurigena Antunes de
Keywords: Atorvastatina cálcica;Abscesso periapical
Issue Date: 2013
Citation: ARAUJO JÚNIOR, Raimundo Fernandes et al . Atorvastatin Decreases Bone Loss, Inflammation and Oxidative Stress in Experimental Periodontitis. Plos One , v. 8, n. 10, p. e75322, 2013.
Portuguese Abstract: The aim of this study is to determine the effects of Atorvastatin treatment, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, in periodontal disease. Male Wistar albino rats were randomly divided into five groups of ten rats each: (1) non-ligated treatment (NL), (2) ligature only (L), (3) ligature plus 1 mg/kg Atorvastatin daily for 10 days, (4) ligature plus 5 mg/kg Atorvastatin daily for 10 days, and (5) ligature plus 10 mg/kg Atorvastatin daily for 10 days. Following the treatment course, the periodontal tissue of the animals was analyzed by Measurement of alveolar bone loss, Histopathology and immunohistochemistry to determine of the expression of COX-2, MMP-2, MMP9, and RANKL/RANK/OPG. ELISA assay was used to quantitate the levels of IL-1β, IL-10, TNF-α, myeloperoxidase, malondialdehyde, and glutathione. The periodontal group treated with 10 mg/kg of Atorvastatin (3.9±0.9 mm; p<0.05) showed reverse the alveolar bone loss caused Experimental Periodontal Disease compared to (L) (7.02±0.17 mm). The periodontal group treated with 10 mg/kg of Atorvastatin showed a significant reduction in MPO and MDA (p<0.05) compared to ligature only group (L). Similarly in this group, the levels of the proinflammatory cytokines IL-1β and TNF-α were significantly decreased (p<0.05). Furthermore, MMP-2, MMP-9, RANKL/RANK, and COX-2 were all downregulated by Atorvastatin treatment, while OPG expression was increased. The findings support a role of Atorvastatin for reducing the bone loss, inflammatory response, oxidative stress, and expression of extracellular matrix proteins, while reducing RANK/RANKL and increase OPG in periodontal disease.
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