Please use this identifier to cite or link to this item:
|Title:||Olfactory bulb drives respiration-coupled beta oscillations in the rat hippocampus|
|Authors:||Lockmann, André LV|
Laplagne, Diego Andrés
Tort, Adriano Bretanha Lopes
|Keywords:||granger causality;brain oscillations;cross-frequency coupling;local field potentials;phase coherence|
|Portuguese Abstract:||The synchronization of neuronal oscillations has been suggested as a mechanism to coordinate information flow between distant brain regions. In particular, the olfactory bulb (OB) and the hippocampus (HPC) have been shown to exhibit oscillations in the beta frequency range (10-20 Hz) that are likely to support communication between these structures. Here we further characterize features of beta oscillations in OB and HPC of rats anesthetized with urethane. We find that beta oscillations simultaneously appear in HPC and OB and phase-lock across structures. Moreover, Granger causality analysis reveals that OB beta activity drives HPC beta. The laminar voltage profile of beta in HPC shows the maximum amplitude in the dentate gyrus, spatially coinciding with olfactory inputs to this region. Finally, we also find that the respiratory cycle and respiration-coupled field potential rhythms (1-2 Hz) - but not theta oscillations (3-5 Hz) - modulate beta amplitude in OB and HPC. In all, our results support the hypothesis that beta activity mediates the communication between olfactory and hippocampal circuits in the rodent brain. This article is protected by copyright. All rights reserved.|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.