Please use this identifier to cite or link to this item:
Title: Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor
Authors: Barbosa, Carlos Augusto Galvão
Pinto, Leão Pereira
Freitas, Roseana de Almeida
Costa, Antonio de Lisboa Lopes
Souza, Lélia Batista de
Keywords: Ameloblastoma;Adenomatoid odontogenic tumor;PCNA;p53 protein
Issue Date: 2005
Publisher: SCIELO
Citation: BARBOSA, Carlos Augusto Galvão et al. Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor. Brazilian Dental Journal, v. 16, n. 1, p. 56-61, 2005.
Portuguese Abstract: In this study, proliferating cell nuclear antigen (PCNA) and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor (AOT). The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some specimens, more than one histologic subtype was identified in the same lesion, and each tumor was categorized according to the predominant cell pattern. The odontogenic tumors were grouped as follows: follicular ameloblastoma (n=7), plexiform ameloblastoma (n=4), acanthomatous + follicular ameloblastoma (n=3), basal cell ameloblastoma (n=2), adenomatoid odontogenic tumor (n=8). PCNA immunohistochemical expression revealed stronger quantitative labeling index for the follicular ameloblastoma, while for p53 protein the strongest quantitative labeling index was detected in the plexiform type. Nevertheless, statistical analysis using ANOVA and Tukey's test did not detect significant differences (p>0.05) among the histologic subtypes of ameloblastoma. The findings of this study suggest that the different histologic patterns of ameloblastoma did not show a direct correlation with their clinical behavior and consequently with the prognosis of the cases. The results also indicated that the ameloblastoma has greater proliferative potential than the AOT, which can contribute to explain its more aggressive and invasive characteristics.
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ProliferatingCellNuclearAntigen_Barbosa_2005.pdf327,46 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.