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Title: Morphological changes in the suprachiasmatic nucleus of aging female marmosets (callithrix jacchus)
Authors: Engelberth, Rovena Clara G. J.
Silva, Kayo Diogenes de A.
Azevedo, Carolina V. de M.
Gavioli, Elaine Cristina
Santos, Jose Ronaldo dos
Soares, Joacil Germano
Nascimento Junior, Expedito S.
Cavalcante, Judney C.
Costa, Miriam Stela M. O.
Cavalcante, Jeferson S.
Keywords: Suprachiasmatic;Pacemaker;NeuN-IR
Issue Date: 2014
Publisher: Hindawi Publishing Corporation
Citation: ENGELBERTH, Rovena Clara G. J. et al. Morphological changes in the suprachiasmatic nucleus of aging female marmosets (callithrix jacchus). BioMed Research International, p. 1-10, 2014. Disponível em <>. Acesso em: 20 nov. 2017.
Portuguese Abstract: The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging
ISSN: 2314-6133
Appears in Collections:CB - DBIO - Artigos publicados em periódicos

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