Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/25346
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dc.contributor.authorQueiroz, Alexandre F.S.-
dc.contributor.authorMoura, Raniere M.-
dc.contributor.authorRibeiro, Jannison K.C.-
dc.contributor.authorLyra, Ibson L.-
dc.contributor.authorCunha, Dayse C.S.-
dc.contributor.authorSantos, Elizeu A.-
dc.contributor.authorde-Sales, Maurício. P.-
dc.date.accessioned2018-06-12T12:56:24Z-
dc.date.available2018-06-12T12:56:24Z-
dc.date.issued2007-
dc.identifier.citationQueiroz, Alexandre F.S.; Moura, Raniere M.; Ribeiro, Jannison K.C.; Lyra, Ibson L.; Cunha, Dayse C.S.; Santos, Elizeu A.; de-Sales, Maurício. P. Pro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varians. Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology, v. 147, p. 216-221, 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1532045607002074>. Acesso em: 04 mar. 2018pt_BR
dc.identifier.issn0010-406X-
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25346-
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.subjectMarine spongept_BR
dc.subjectCliona varianspt_BR
dc.subjectLeukocyte migrationpt_BR
dc.subjectPaw oedemapt_BR
dc.subjectPeritonitispt_BR
dc.titlePro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varianspt_BR
dc.typearticlept_BR
dc.identifier.doi10.1016/j.cbpc.2007.09.008-
dc.description.resumoCvL, a lectin from the marine sponge Cliona varians agglutinated type A papainized erythrocytes and was strongly inhibited by D-galactose and sucrose. Models of leukocyte migration in vivo were used to study the inflammatory activity of CvL through of mouse paw oedema and peritonitis. Effect of CvL on peritoneal macrophage activation was analysed. Effects of corticoids and NSAIDS drugs were also evaluated on peritonitis stimulated by CvL. Results showed that mouse hind-paw oedema induced by subplantar injections of CvL was dose dependent until 50 μg/cavity. This CvL dose when administered into mouse peritoneal cavities induced maxima cell migration (9283 cells/μL) at 24 h after injection. This effect was preferentially inhibited by incubation of CvL with the carbohydrates D-galactose followed by sucrose. Pre-treatment of mice with 3% thioglycolate increases the peritoneal macrophage population 2.3 times, and enhanced the neutrophil migration after 24 h CvL injection (75.8%, pb0.001) and no significant effect was observed in the presence of fMLP. Finally, pre-treatment of mice with dexamethasone (cytokine antagonist) decreased (65.6%, pb0.001), diclofenac (non-selective NSAID) decreased (34.5%, pb0.001) and Celecoxib (selective NSAID) had no effect on leukocyte migration after submission at peritonitis stimulated by CvL, respectively. Summarizing, data suggest that CvL shows pro-inflammatory activity, inducing neutrophil migration probably by pathway on resident macrophage activation and on chemotaxis mediated by cytokines.pt_BR
Appears in Collections:CB - DBF - Artigos publicados em periódicos

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