1. Universidade Federal do Rio Grande do Norte
2. Centro de Biociências
3. DBQ - Departamento de Bioquímica
4. CB - DBQ - Artigos publicados em periódicos

Título:	Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities
Autor(es):	Camara, Rafael Barros Gomes Costa, Leandro Silva Fidelis, Gabriel Pereira Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Cordeiro, Sara Lima Costa, Mariana Santana Santos Pereira Alves, Luciana Guimaraes Rocha, Hugo Alexandre de Oliveira
Palavras-chave:	Dictyota cervicornis;Fucoidan;Free radicals;Sulfated polysaccharides
Data do documento:	24-Jan-2011
Editor:	MDPI
Referência:	CAMARA, Rafael Barros Gomes da; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CORDEIRO, Sara Lima; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities. Marine Drugs, [s. l.], v. 9, n. 1, p. 124-138, 24 jan. 2011. MDPI AG. http://dx.doi.org/10.3390/md9010124. Disponível em: https://www.mdpi.com/1660-3397/9/1/124. Acesso em: 16 set. 2020.
Resumo:	Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation. These heterofucans are composed mainly of fucose, glucuronic acid, galactose and sulfate. No polysaccharide was capable of prolonging prothrombin time (PT) at the concentration assayed. However, all polysaccharides prolonged activated partial thromboplastin time (aPTT). Four sulfated polysaccharides (CC-0.3/CC-0.5/CC-0.7/CC-1.0) doubled aPTT with only 0.1 mg/mL of plasma, only 1.25-fold less than Clexane®, a commercial low molecular weight heparin. Heterofucans exhibited total antioxidant capacity, low hydroxyl radical scavenging activity, good superoxide radical scavenging efficiency (except CC-1.0), and excellent ferrous chelating ability (except CC-0.3). These results clearly indicate the beneficial effect of C. cervicornis polysaccharides as anticoagulants and antioxidants. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents
URI:	https://repositorio.ufrn.br/handle/123456789/31326
ISSN:	1660-3397 (online)
Aparece nas coleções:	CB - DBQ - Artigos publicados em periódicos

Este item está licenciada sob uma Licença Creative Commons