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https://repositorio.ufrn.br/handle/123456789/31328| Título: | Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula |
| Autor(es): | Magalhaes, Kaline Dantas Costa, Leandro Silva Fidelis, Gabriel Pereira Oliveira, Ruth Medeiros Nobre, Leonardo Thiago Duarte Barreto Dantas-Santos, Nednaldo Câmara, Rafael Barros Gomes da Albuquerque, Ivan Rui Lopes Cordeiro, Sara Lima Sabry, Diego Araujo Costa, Mariana Santana Santos Pereira Alves, Luciana Guimaraes Rocha, Hugo Alexandre de Oliveira |
| Palavras-chave: | Fucoidan;Brown seaweed;Biological activities;Sulfated polysaccharides |
| Data do documento: | 23-Mai-2011 |
| Editor: | MDPI |
| Referência: | MAGALHÃES, Kaline Dantas; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; ALBUQUERQUE, Ivan Rui Lopes; CORDEIRO, Sara Lima; SABRY, Diego Araujo; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula. International Journal of Molecular Sciences, [s. l.], v. 12, p. 3352-3365, 2011. http://dx.doi.org/10.3390/ijms12053352. Disponível em: https://www.mdpi.com/1422-0067/12/5/3352. Acesso em: 25 set. 2020. |
| Resumo: | In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress |
| URI: | https://repositorio.ufrn.br/handle/123456789/31328 |
| ISSN: | 1422-0067 (online) 1661-6596 (print) |
| Aparece nas coleções: | CB - DBQ - Artigos publicados em periódicos |
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| AnticoagulantAntioxidantAntitumor_Nobre_2011.pdf | 426,37 kB | Adobe PDF |  Visualizar/Abrir |
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