1. Universidade Federal do Rio Grande do Norte
  2. Centro de Biociências
  3. DBQ - Departamento de Bioquímica
  4. CB - DBQ - Artigos publicados em periódicos
Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/handle/123456789/31328
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dc.contributor.authorMagalhaes, Kaline Dantas-
dc.contributor.authorCosta, Leandro Silva-
dc.contributor.authorFidelis, Gabriel Pereira-
dc.contributor.authorOliveira, Ruth Medeiros-
dc.contributor.authorNobre, Leonardo Thiago Duarte Barreto-
dc.contributor.authorDantas-Santos, Nednaldo-
dc.contributor.authorCâmara, Rafael Barros Gomes da-
dc.contributor.authorAlbuquerque, Ivan Rui Lopes-
dc.contributor.authorCordeiro, Sara Lima-
dc.contributor.authorSabry, Diego Araujo-
dc.contributor.authorCosta, Mariana Santana Santos Pereira-
dc.contributor.authorAlves, Luciana Guimaraes-
dc.contributor.authorRocha, Hugo Alexandre de Oliveira-
dc.date.accessioned2021-01-29T19:39:11Z-
dc.date.available2021-01-29T19:39:11Z-
dc.date.issued2011-05-23-
dc.identifier.citationMAGALHÃES, Kaline Dantas; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; ALBUQUERQUE, Ivan Rui Lopes; CORDEIRO, Sara Lima; SABRY, Diego Araujo; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula. International Journal of Molecular Sciences, [s. l.], v. 12, p. 3352-3365, 2011. http://dx.doi.org/10.3390/ijms12053352. Disponível em: https://www.mdpi.com/1422-0067/12/5/3352. Acesso em: 25 set. 2020.pt_BR
dc.identifier.issn1422-0067 (online)-
dc.identifier.issn1661-6596 (print)-
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31328-
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectFucoidanpt_BR
dc.subjectBrown seaweedpt_BR
dc.subjectBiological activitiespt_BR
dc.subjectSulfated polysaccharidespt_BR
dc.titleAnticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatulapt_BR
dc.typearticlept_BR
dc.identifier.doi10.3390/ijms12053352-
dc.description.resumoIn the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progresspt_BR
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