Cell therapy for stroke: use of local astrocytes

Chouchane, Melek; Costa, Marcos Romualdo

Cell therapy for stroke: use of local astrocytes

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dc.contributor.author	Chouchane, Melek
dc.contributor.author	Costa, Marcos Romualdo
dc.date.accessioned	2017-05-29T14:11:33Z
dc.date.available	2017-05-29T14:11:33Z
dc.date.issued	2012-10-31
dc.description.resumo	Stroke refers to a variety of conditions caused by the occlusion or hemorrhage of blood vessels supplying the brain, which is one of the main causes of death and the leading cause of disability worldwide. In the last years, cell-based therapies have been proposed as a new approach to ameliorate post-stroke deficits. However, the most appropriate type of cell to be used in such therapies, as well as their sources, remains a matter of intense research. A good candidate cell should, in principle, display high plasticity to generate diverse types of neurons and, at the same time, low risk to cause undesired outcomes, such as malignant transformation. Recently, a new approach grounded on the reprogramming of endogenous astrocytes toward neuronal fates emerged as an alternative to restore neurological functions in several central nervous system diseases. In this perspective, we review data about the potential of astrocytes to become functional neurons following expression of neurogenic genes and discuss the potential benefits and risks of reprogramming astrocytes in the glial scar to replace neurons lost after stroke.	pt_BR
dc.identifier.issn	1662-5102
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23175
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	stroke	pt_BR
dc.subject	neuronal replacement	pt_BR
dc.subject	astrocyte reprogramming	pt_BR
dc.title	Cell therapy for stroke: use of local astrocytes	pt_BR
dc.type	article	pt_BR