Phytochemical content, antioxidant, anti-inflammatory activities and wound healing properties of freeze-dried fruits

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dc.contributor.authorMoraes, Francisca Pereira de
dc.contributor.authorXiong, Jia
dc.contributor.authorBorges, Katia Cristina
dc.contributor.authorHoskin, Roberta Targino
dc.contributor.authorEsposito, Debora
dc.date.accessioned2021-12-16T12:31:28Z
dc.date.available2021-12-16T12:31:28Z
dc.date.issued2020-01-01
dc.description.resumoThis work evaluated the phytochemical composition of freeze-dried acerola, camu-camu, apple and pineapple extracts, and correlated it with their cell-based in vitro antioxidant, anti-inflammatory and wound healing activities. All freeze-dried fruit extracts at 50 µm/mL significantly inhibited (p<0.001) reactive oxygen species (ROS) up to 70%, but only acerola and camu-camu extracts at 150 µm/mL decreased (p<0.001) the nitric oxide (NO) production (up to 33%) in LPS-stimulated RAW 264.7 macrophages. When selected mRNA biomarkers of acute inflammation were evaluated, all freeze-dried fruit extracts inhibited the expression of IL-6 and IL-1β genes, but only acerola reduced the COX-2 expression (p<0.01). In addition, freeze-dried acerola extract (50 µm/mL) significantly enhanced human dermal fibroblasts (HDFa) migration by 1.5-fold compared to the control after 36 h. Based on our results, we hypothesize that the high concentration of ascorbic acid (9454.3 mg/100 g) and anthocyanin contents (14.0 mg /100 g) of freezedried acerola may play an important role on the in vitro biological resultspt_BR
dc.identifier.citationMORAES, Francisca Pereira de; XIONG, Jia; BORGES, Katia Cristina; HOSKIN, Roberta Targino; ESPOSITO, Debora. Phytochemical Content, Antioxidant, Anti-inflammatory Activities and Wound Healing Properties of Freeze-Dried Fruits. Acta Scientifci Nutritional Health, v. 4, p. 63-71, 2019. Disponível em: https://actascientific.com/ASNH/pdf/ASNH-04-0576.pdf. Acesso em: 04 nov. 2021. https://doi.org/10.31080/ASNH.2020.04.0576pt_BR
dc.identifier.doi10.31080/ASNH.2020.04.0576
dc.identifier.issn2582-1423
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45387
dc.languageenpt_BR
dc.publisherActa Scientific Nutritional Healthpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectAscorbic Acidpt_BR
dc.subjectInflammationpt_BR
dc.subjectAcerolapt_BR
dc.subjectWound Healingpt_BR
dc.subjectEdible Fruitspt_BR
dc.titlePhytochemical content, antioxidant, anti-inflammatory activities and wound healing properties of freeze-dried fruitspt_BR
dc.typearticlept_BR

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