Adult neural stem cells: plastic or restricted neuronal fates?

dc.contributor.author	Sequerra, Eduardo Bouth
dc.contributor.author	Costa, Marcos Romualdo
dc.contributor.author	Menezes, João R. L.
dc.contributor.author	Hedin-Pereira, Cecilia
dc.date.accessioned	2017-05-31T15:07:18Z
dc.date.available	2017-05-31T15:07:18Z
dc.date.issued	2013
dc.description.resumo	During embryonic development, the telencephalon is specified along its axis through morphogenetic gradients, leading to the positional-dependent generation of multiple neuronal types. After embryogenesis, however, the fate of neuronal progenitors becomes more restricted, and they generate only a subset of neurons. Here, we review studies of postnatal and adult neurogenesis, challenging the notion that fixed genetic programs restrict neuronal fate. We hypothesize that the adult brain maintains plastic neural stem cells that are capable of responding to changes in environmental cues and generating diverse neuronal types. Thus, the limited diversity of neurons generated under normal conditions must be actively maintained by the adult milieu.	pt_BR
dc.identifier.doi	10.1242/dev.093096
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23285
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Adult neurogenesis	pt_BR
dc.subject	Cerebral cortex	pt_BR
dc.subject	Neuronal specification	pt_BR
dc.subject	Olfactory bulb	pt_BR
dc.subject	Subventricular zone	pt_BR
dc.title	Adult neural stem cells: plastic or restricted neuronal fates?	pt_BR
dc.type	article	pt_BR