Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip

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dc.contributor.authorSilveira, Ericka Janine Dantas da
dc.contributor.authorMiguel, Marcia Cristina da Costa
dc.contributor.authorLima, Kenio Costa de
dc.contributor.authorFreitas, Roseana de Almeida
dc.contributor.authorMorais, Maria de Lourdes Silva Arruda de
dc.contributor.authorQueiroz, Lelia Maria Guedes
dc.date.accessioned2017-01-30T13:04:05Z
dc.date.available2017-01-30T13:04:05Z
dc.date.issued2010
dc.description.resumoAntitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.pt_BR
dc.identifier.citationSILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/21801
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subjectTonguept_BR
dc.subjectLower lippt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectLocal immune responsept_BR
dc.titleAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lippt_BR
dc.typearticlept_BR

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