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Title: Effects of Purified Saccharomyces cerevisiae (1→3)-β-Glucan on Venous Ulcer Healing
Authors: Medeiros, Sarah Dantas Viana
Cordeiro, Sara Lima
Cavalcanti, Jéssica Escorel Chaves
Melchuna, Karina Mendes
Lima, Aleida Maria da Silva
Araújo Filho, Irami
Medeiros, Aldo Cunha
Rocha, Keyla Borges Ferreira
Oliveira, Elizabeth Maia
Faria, Eduardo Dantas Baptista
Sassaki, Guilherme Lanzi
Rocha, Hugo Alexandre Oliveira
Sales, Valéria Soraya Farias
Keywords: water-insoluble glucan;polysaccharide;yeast;immunomodulator;tissue repair
Issue Date: 2-Jul-2012
Citation: MEDEIROS, Aldo Cunha et al. Effects of Purified Saccharomyces cerevisiae (1→3)-β-Glucan on Venous Ulcer Healing. International Journal of Molecular Sciences, v. 13, p. 8142-8158, 2012. Disponível em:<>. Acesso em: 01 ago. 2013.
Abstract: Water-insoluble glucan was isolated from the baker’s yeast Saccharomyces cerevisiae. The yeast cells were treated with alkali and the residue then with acid. Chemical and NMR (1D and 2D) analyses showed that a linear (1→3)-β-glucan was purified that was not contaminated with other carbohydrates, proteins or phenolic compounds. The effects of the glucan on wound healing were assessed in human venous ulcers by histopathological analysis after 30 days of topical treatment. (1→3)-β-glucan enhanced ulcer healing and increased epithelial hyperplasia, as well as increased inflammatory cells, angiogenesis and fibroblast proliferation. In one patient who had an ulcer that would not heal for over 15 years, glucan treatment caused a 67.8% decrease in the area of the ulcer. This is the first study to investigate the effects of (1→3)-β-glucan on venous ulcer healing in humans; our findings suggest that this glucan is a potential natural biological response modifier in wound healing
ISSN: 1422-0067
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos

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