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https://repositorio.ufrn.br/handle/123456789/18984
Title: | Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences |
Authors: | Costa, Marcos Romualdo Ulrich Müller |
Keywords: | cerebral cortex;developmen;excitatory neurons;progenitor diversity;neuronal specification |
Issue Date: | 12-Jan-2015 |
Citation: | COSTA, Marcos R.; MÜLLER, Ulrich. Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences. Fontiers in Celular Neuroscience. v.8, jan. 2015. doi: 10.3389/fncel.2014.00449. |
Abstract: | The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate. |
URI: | https://repositorio.ufrn.br/jspui/handle/123456789/18984 |
ISSN: | 1662-5102 |
Appears in Collections: | ICe - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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MarcosCosta_ICE_2015_Specification of excitatory.pdf | Artigo completo | 602,95 kB | Adobe PDF | View/Open |
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