Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/19273
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dc.contributor.authorDupnik, Kathryn M.-
dc.contributor.authorBair, Thomas B.-
dc.contributor.authorMaia, Andressa O.-
dc.contributor.authorAmorim, Francianne M.-
dc.contributor.authorCosta, Marcos R.-
dc.contributor.authorKeesen, Tatjana S. L.-
dc.contributor.authorValverde, Joanna G.-
dc.contributor.authorQueiroz, Maria do Carmo A. P.-
dc.contributor.authorMedeiros, Lúcio L.-
dc.contributor.authorLucena, Nelly L. de-
dc.contributor.authorWilson, Mary E.-
dc.contributor.authorNobre, Mauricio L.-
dc.contributor.authorJohnson Jr, Warren D.-
dc.contributor.authorJeronimo, Selma M. B.-
dc.date.accessioned2015-09-25T19:57:56Z-
dc.date.available2015-09-25T19:57:56Z-
dc.date.issued2014-
dc.identifier.citationDUPNIK, Kathryn M. et al. Transcriptional Changes That Characterize the Immune Reactions of Leprosy. Journal of Infectious Diseases, v. 211, n. 10. 14 nov. 2014.pt_BR
dc.identifier.urihttp://repositorio.ufrn.br/handle/123456789/19273-
dc.description.abstractBackground: Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL). Methods: To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry. Results: There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the “complement and coagulation” pathway common to both. Interferon γ was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL. Conclusions: These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis.pt_BR
dc.language.isoengpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectleprosypt_BR
dc.subjectreversal reactionpt_BR
dc.subjecterythema nodosum leprosumpt_BR
dc.subjectcomplementpt_BR
dc.titleTranscriptional Changes That Characterize the Immune Reactions of Leprosypt_BR
dc.typearticlept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFRNpt_BR
dc.description.resumoBackground: Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL). Methods: To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry. Results: There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the “complement and coagulation” pathway common to both. Interferon γ was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL. Conclusions: These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis.pt_BR
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