Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/22855
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dc.contributor.authorAndino-Pavlovsky, Victoria-
dc.contributor.authorSouza, Annie C.-
dc.contributor.authorScheffer-Teixeira, Robson-
dc.contributor.authorTort, Adriano B. L.-
dc.contributor.authorEtchenique, Roberto-
dc.contributor.authorRibeiro, Sidarta-
dc.date.accessioned2017-05-10T12:08:30Z-
dc.date.available2017-05-10T12:08:30Z-
dc.date.issued2017-05-09-
dc.identifier.urihttp://hdl.handle.net/123456789/22855-
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLFP oscillationpt_BR
dc.subjectcomodulationpt_BR
dc.subjectdelta-gamma couplingpt_BR
dc.subjectuncagingpt_BR
dc.subjectdopaminept_BR
dc.titleDopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Ratspt_BR
dc.typearticlept_BR
dc.identifier.doi10.3389/fncir.2017.00029-
dc.description.resumoDopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC.pt_BR
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