Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/23133
Título: Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
Autor(es): Scheffer-Teixeira, Robson
Belchior, Hindiael
Caixeta, Fábio V.
Souza, Bryan C.
Ribeiro, Sidarta
Tort, Adriano B. L.
Palavras-chave: amplitude modulation;cross-frequency coupling;gamma;hippocampal oscillations;local field potential
Data do documento: 10-Nov-2011
metadata.dc.description.resumo: It was recently proposed that fast gamma oscillations (60--150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ~80 Hz and a faster oscillation centered at ~140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-- moleculare, while theta-140 Hz coupling is strongest at stratum oriens--alveus. This laminar profile suggests that the ~80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ~140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ~140 Hz oscillation differs from sharp wave--associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta--associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations.
URI: http://hdl.handle.net/123456789/23133
ISSN: 1047-3211
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