Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits

Ludmyla Kandratavicius; Cleiton Lopes-Aguiar; Lézio Soares Bueno-Júnior; Rodrigo Neves Romcy-Pereira; Jaime Eduardo Cecilio Hallak; João Pereira Leite

Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/handle/123456789/23267

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Campo DC	Valor	Idioma
dc.contributor.author	Ludmyla Kandratavicius	-
dc.contributor.author	Cleiton Lopes-Aguiar	-
dc.contributor.author	Lézio Soares Bueno-Júnior	-
dc.contributor.author	Rodrigo Neves Romcy-Pereira	-
dc.contributor.author	Jaime Eduardo Cecilio Hallak	-
dc.contributor.author	João Pereira Leite	-
dc.date.accessioned	2017-05-31T12:49:38Z	-
dc.date.available	2017-05-31T12:49:38Z	-
dc.date.issued	2012-04-23	-
dc.identifier.issn	1516-4446	-
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23267	-
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Temporal Lobe	pt_BR
dc.subject	Epilepsy	pt_BR
dc.subject	Psychosis	pt_BR
dc.subject	Psychiatric	pt_BR
dc.subject	Comorbidities	pt_BR
dc.subject	Neuropathology	pt_BR
dc.subject	Limbic Circuits	pt_BR
dc.title	Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits	pt_BR
dc.type	article	pt_BR
dc.description.resumo	Objective: Mounting evidence suggests that the limbic system is pathologically involved in cases of psychiatric comorbidities in temporal lobe epilepsy (TLE) patients. Our objective was to develop a conceptual framework describing how neuropathological and connectivity changes might contribute to the development of psychosis and to the potential neurobiological mechanisms that cause schizophrenia-like psychosis in TLE patients. Methods: In this review, clinical and neuropathological findings, especially brain circuitry of the limbic system, were examined together to enhance our understanding of the association between TLE and psychosis. Finally, the importance of animal models in epilepsy and psychiatric disorders was discussed. Conclusions: TLE and psychiatric symptoms coexist more frequently than chance would predict. Damage and deregulation among critical anatomical regions, such as the hippocampus, amygdala, thalamus, and the temporal, frontal and cingulate cortices, might predispose TLE brains to psychosis. Studies of the effects of kindling and injection of neuroactive substances on behavior and electrophysiological patterns may offer a model of how limbic seizures in humans increase the vulnerability of TLE patients to psychiatric symptoms	pt_BR
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