1. Universidade Federal do Rio Grande do Norte
2. Instituto do Cérebro
3. ICe - Artigos publicados em periódicos

Título:	Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons
Autor(es):	Anders Enjin, Katarina E. Leão Sanja Mikulovic, Pierre Le Merre Warren G. Tourtellotte, Klas Kullander
Palavras-chave:	5-ht1d;Serotonin;Gamma motor neurons;Muscle spindle;Fusimotor system;Spinal cord;Proprioception;Motor behavior
Data do documento:	17-Jan-2012
Resumo:	Gamma motor neurons (MNs), the efferent component of the fusimotor system, regulate muscle spindle sensitivity. Muscle spindle sensory feedback is required for proprioception that includes sensing the relative position of neighboring body parts and appropriately adjust the employed strength in a movement. The lack of a single and specific genetic marker has long hampered functional and developmental studies of gamma MNs. Here we show that the serotonin receptor 1d (5-ht1d) is specifically expressed by gamma MNs and proprioceptive sensory neurons. Using mice expressing GFP driven by the 5-ht1d promotor, we performed wholecell patch-clamp recordings of 5-ht1d::GFP+ and 5-ht1d::GFP− motor neurons from young mice. Hierarchal clustering analysis revealed that gamma MNs have distinct electrophysiological properties intermediate to fast-like and slow-like alpha MNs. Moreover, mice lacking 5-ht1d displayed lower monosynaptic reflex amplitudes suggesting a reduced response to sensory stimulation in motor neurons. Interestingly, adult 5-ht1d knockout mice also displayed improved coordination skills on a beam-walking task, implying that reduced activation of MNs by Ia afferents during provoked movement tasks could reduce undesired exaggerated muscle output. In summary, we show that 5-ht1d is a novel marker for gamma MNs and that the 5-ht1d receptor is important for the ability of proprioceptive circuits to receive and relay accurate sensory information in developing and mature spinal cord motor circuits.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/23272
ISSN:	1044-7431
Aparece nas coleções:	ICe - Artigos publicados em periódicos

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