Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/23321
Title: Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
Authors: Katche, Cynthia
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martín
Medina, Jorge H.
Keywords: memory;cortical plasticity;post-training macromolecular synthesis;retrosplenial cortex
Issue Date: 2013
Portuguese Abstract: Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.
URI: http://hdl.handle.net/123456789/23321
Appears in Collections:ICe - Artigos publicados em periódicos

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