Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/23434
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dc.contributor.authorChouchane, Malek-
dc.contributor.authorFaria, Ana Raquel Melo de-
dc.contributor.authorMoura, Daniela Maria de Souza-
dc.contributor.authorHilscher, Markus Michael-
dc.contributor.authorSchroder, Timm-
dc.contributor.authorLeão, Richardson-
dc.contributor.authorCosta, Marcos Romualdo-
dc.date.accessioned2017-06-08T16:24:43Z-
dc.date.available2017-06-08T16:24:43Z-
dc.date.issued2017-07-
dc.identifier.issn2213-6711-
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23434-
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectLineage reprogrammingpt_BR
dc.subjectInduced neuronspt_BR
dc.subjectProneural genespt_BR
dc.subjectAstroglial cellspt_BR
dc.subjectCerebral cortexpt_BR
dc.subjectCerebellumpt_BR
dc.subjectCell transplantationpt_BR
dc.titleLineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypespt_BR
dc.typearticlept_BR
dc.description.resumoAstroglial cells isolated from the rodent postnatal cerebral cortex are particularly susceptible to lineage reprogramming into neurons. However, it remains unknown whether other astroglial populations retain the same potential. Likewise, little is known about the fate of induced neurons (iNs) in vivo. In this study we addressed these questions using two different astroglial populations isolated from the postnatal brain reprogrammed either with Neurogenin-2 (Neurog2) or Achaete scute homolog-1 (Ascl1). We show that cerebellum (CerebAstro) and cerebral cortex astroglia (CtxAstro) generates iNs with distinctive neurochemical and morphological properties. Both astroglial populations contribute iNs to the olfactory bulb following transplantation in the postnatal and adult mouse subventricular zone. However, only CtxAstro transfected with Neurog2 differentiate into pyramidal-like iNs after transplantation in the postnatal cerebral cortex. Altogether, our data indicate that the origin of the astroglial population and transcription factors used for reprogramming, as well as the region of integration, affect the fate of iNs.pt_BR
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