1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DOD - Departamento de Odontologia
4. CCS - DOD - Artigos publicados em periódicos

Título:	Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
Autor(es):	Cavalcante, Roberta Barroso Alves, Karuza Maria Nonaka, Cassiano Francisco Weege Souza, Lélia Batista de
Palavras-chave:	Immunohistochemistry
Data do documento:	2008
Referência:	CAVALCANTE, Roberta Barroso et al . Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 1, p. 923-929, 2008.
Resumo:	Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/23860
Aparece nas coleções:	CCS - DOD - Artigos publicados em periódicos

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