Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/23868
Title: Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics.
Authors: Andrade, Emanuel Sávio de Souza
Miguel, Marcia Cristina da Costa
Pinto, Leão Pereira
Souza, Lélia Batista de
Keywords: Ameloblastoma;Adenomatoid odontogenic tumor;Integrins
Issue Date: 2007
Citation: Andrade, Emanuel Sávio de Souza et al. Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics. Annals of Diagnostic Pathology, v. 11, n. 3, p. 199-205, 2007.
Portuguese Abstract: Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and a tendency toward recurrence, whereas adenomatoid odontogenic tumor (AOT) is an indolent neoplasm. The objective of the present study was to immunohistochemically analyze the role of a2b1, a3b1, and a5b1 integrins in the cellular events and cell-matrix interactions that occur in these tumors and their consequent repercussions on the architectural arrangement and biologic behavior of these lesions. Paraffin-embedded specimens from 30 ameloblastomas (20 solid and 10 unicystic tumors) and 12 AOTs were submitted to immunohistochemistry using the catalyzed signal amplification system. A difference in the pattern of integrin expression was observed between the various histologic types of ameloblastoma. No significant difference in labeling intensity was observed between unicystic and solid ameloblastomas, but comparison between ameloblastomas and AOT showed a significantly stronger expression of a5b1 integrin in the former ( P b .05). Our findings suggest an important role of the integrins studied in the architectural characteristics of ameloblastomas and AOTs and a possible participation of a5b1 integrin in the mechanism of local invasion of ameloblastomas
URI: https://repositorio.ufrn.br/jspui/handle/123456789/23868
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