1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DOD - Departamento de Odontologia
4. CCS - DOD - Artigos publicados em periódicos

Título:	Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor
Autor(es):	Barbosa, Carlos Augusto Galvão Pinto, Leão Pereira Freitas, Roseana de Almeida Costa, Antonio de Lisboa Lopes Souza, Lélia Batista de
Palavras-chave:	Ameloblastoma;Adenomatoid odontogenic tumor;PCNA;p53 protein
Data do documento:	2005
Editor:	SCIELO
Referência:	BARBOSA, Carlos Augusto Galvão et al. Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor. Brazilian Dental Journal, v. 16, n. 1, p. 56-61, 2005.
Resumo:	In this study, proliferating cell nuclear antigen (PCNA) and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor (AOT). The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some specimens, more than one histologic subtype was identified in the same lesion, and each tumor was categorized according to the predominant cell pattern. The odontogenic tumors were grouped as follows: follicular ameloblastoma (n=7), plexiform ameloblastoma (n=4), acanthomatous + follicular ameloblastoma (n=3), basal cell ameloblastoma (n=2), adenomatoid odontogenic tumor (n=8). PCNA immunohistochemical expression revealed stronger quantitative labeling index for the follicular ameloblastoma, while for p53 protein the strongest quantitative labeling index was detected in the plexiform type. Nevertheless, statistical analysis using ANOVA and Tukey's test did not detect significant differences (p>0.05) among the histologic subtypes of ameloblastoma. The findings of this study suggest that the different histologic patterns of ameloblastoma did not show a direct correlation with their clinical behavior and consequently with the prognosis of the cases. The results also indicated that the ameloblastoma has greater proliferative potential than the AOT, which can contribute to explain its more aggressive and invasive characteristics.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/23900
Aparece nas coleções:	CCS - DOD - Artigos publicados em periódicos

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