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|Title:||Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT|
Nascimento, Juliana Minardi
Sartore, Rafaela Costa
Maciel, Renata de Moraes
Araujo, Draulio B. de
Rehen, Stevens K.
|Keywords:||5-MeO-DMT;Neural stem cells;Cellular neuroscience;Neuroscience;Proteomics|
|Citation:||DAKIC, V. et al. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Scietific reports, [s. l.], v. 7, p.12863, out./2017.|
|Resumo:||Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. In silico analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. Our data offer the first insight about molecular alterations caused by 5-MeO-DMT in human cerebral organoids.|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
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|DraulioBarros_ICe_2017_Short term.pdf||DraulioBarros_ICe_2017_Short term||4,42 MB||Adobe PDF|
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