1. Universidade Federal do Rio Grande do Norte
  2. Centro de Biociências
  3. DBIO - Departamento Biologia
  4. CB - DBIO - Artigos publicados em periódicos
Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/handle/123456789/24712
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Campo DCValorIdioma
dc.contributor.authorFerreira, Diana Aline Nôga Morais-
dc.contributor.authorCagni, Fernanda Carvalho-
dc.contributor.authorSantos, J. R.-
dc.contributor.authorSilva, D.-
dc.contributor.authorAzevedo, D. L. O.-
dc.contributor.authorAraújo, Arrilton-
dc.contributor.authorSilva, R. H.-
dc.contributor.authorRibeiro, A. M.-
dc.date.accessioned2018-02-07T20:20:45Z-
dc.date.available2018-02-07T20:20:45Z-
dc.date.issued2015-
dc.identifier.citationFERREIRA, Diana Aline Nôga Morais et al. Pro- and anticonvulsant effects of the ant dinoponera quadriceps (Kempf) venom in mice. Neotropical entomology, v. 44, p. 410-417, 2015. Disponível em:<https://link.springer.com/article/10.1007%2Fs13744-015-0292-7>. Acesso em: 19 out. 2017.pt_BR
dc.identifier.issn1519-566X-
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/24712-
dc.languageengpt_BR
dc.publisherSpringerpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBicucullinept_BR
dc.subjectFreezingpt_BR
dc.subjectTonic-clonicpt_BR
dc.subjectWild runningpt_BR
dc.titlePro-and anticonvulsant effects of the ant dinoponera quadriceps (Kempf) venom in micept_BR
dc.typearticlept_BR
dc.identifier.doi10.1007/s13744-015-0292-7-
dc.description.resumoEpilepsy affects at least 50 million people worldwide, and the available treatment is associated with various side effects. Approximately 20–30% of the patients develop seizures that persist despite careful monitored treatment with antiepileptic drugs. Thus, there is a clear need for the development of new antiepileptic drugs, and the venoms can be an excellent source of probes. In this context, while there are studies on venoms from snakes, scorpions, and spiders, little is known regarding venom from ants. The aim of this study was to investigate the potential pro- and anticonvulsant effects of the venom from the ant Dinoponera quadriceps (Kempf) in Swiss mice. After the injection of the crude venom (DqTx—5, 50, and 500 mg/mL) in the lateral ventricle of mice, we observed a reduction of exploration and grooming behaviors, as well as an increase in immobility duration. In addition, the crude venom induced procursive behavior and tonicclonic seizures at the highest concentration. Conversely, the preadministration of the denatured venom (AbDq) at the concentration of 2 mg/mL protected the animals against tonic-clonic seizures (66.7%) and death (100%) induced by administration of bicuculline. Taken together, the findings demonstrate that D. quadriceps venom might be potential source of new pro- and anticonvulsants moleculespt_BR
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